Washington Square Park Chess Covid, Mlb The Show 21 Player Ratings Database, Articles P

Provide oversight to Shared Services Derivatives team supporting RWA operations and production. , McGuire JL. , Mikolaitis-Preuss RA , Gayet-Ageron A , Magder LS Rendas-Baum R, Baranwal N, Joshi AV, Park J, Kosinski M. J Patient Rep Outcomes. , Kostopoulou M Stojan G Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. Flow chart illustrating the literature search and study selection. Barr et al. A good responsiveness for PGA was shown in eight studies. , Aggarwal R The interrater reliability (interRR) of the PGA is the ability to provide consistent scores in a stable population between two or more physicians who evaluate the disease activity of the same patient. , Brunetta P The index has proved quick and easy to use despite a comprehensive database and compares favourably with . Objectives Remission in systemic lupus erythematosus (SLE) is defined through a combination of 'clinical SLE Disease Activity Index (cSLEDAI)=0', 'physician's global assessment (PGA) <0.5 . Devilliers H Improving patient pathways for systemic lupus erythematosus: a multistakeholder pathway optimisation study. Construct validity was demonstrated by a good correlation (r 0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). , Khamashta MA , Socher SA , Petri MA Conducting medical monitoring, safety review, narrative writing and etc.. Perform medical assessment of individual . It is therefore desirable to use the PGA along with other tools (typically the SLEDAI) or to include the PGA in a composite index (e.g. The anonymous patientcompleted questionnaire comprised the following: current pain in the past 7 days (10cm VAS [0 no pain; 10 most severe pain]), patient global assessment (PtGA) of health status (10 cm VAS [0 very well; 10 very poorly]), ever and current recreational cannabis use, ever and current medical cannabis use, and if cannabis . Truth refers to whether the measure provided by the scores is able to measure what was intended [18]. [2, 21, 24] recommended PGA assessment prior to reviewing serological data, based only on the clinical visit. , Shea BJ Of note, it is not trivial that we found a good convergent validity with other instruments (SLEDAI, BILAG, LAI, SLAM and ECLAM) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. Correspondence to: Laurent Arnaud, Service de Rhumatologie, Centre National de Rfrence des Maladies Autoimmunes et Systmiques Rares, Hpital de Hautepierre, 1 Avenue Molire BP 83049, 67098 Strasbourg Cedex, France. The Physician Global Assessment (PGA) is an important tool for assessing disease activity in lupus. Few studies reported on whether serological activity should be incorporated in the PGA. The Physician's Global Assessment (PhGA) is a number without unit. No data were found regarding the feasibility of the PGA. In 11 retrieved studies [10, 13, 33, 36, 45, 48, 50, 55, 56, 65, 96] the PGA was part of the SFI [104] and in 10 studies [3, 29, 40, 46, 52, 60, 69, 80, 94, 98] it was part of the SRI [3] (both discussed in the Responsiveness section). , Holland M Mahler M Definition: At least a 20%, 40%, 50%, or 70% improvement and an absolute improvement of at least 1 unit on a scale of 1-10 in at least three of the following criteria: patient global assessment; pain; function (BASFI); and. Meta-analysis of the studies reporting data concerning the construct validity between the PGA and SLEDAI. Arriens C FOIA Objective: lupus erythematosus; systemic outcome assessment; qualitative research; healthcare; We read with great interest the recent paper by Aranow et al 1 about the impact of laboratory results on scoring of the Physician Global Assessment (PGA) of disease activity in systemic lupus erythematosus (SLE). Chaigne B However, it was used as a single outcome measure only in two studies [49, 100], while in the majority the PGA was scored together with another instrument (typically the SLEDAI) [2, 9, 11, 12, 21, 24, 30, 32, 34, 3740, 44, 45, 48, 49, 55, 58, 59, 61, 63, 64, 66, 67, 74, 75, 80, 82, 86, 8995, 103]. disease activity). , Rodrigues M , Perez-Gutthann S , Kandane-Rathnayake RK , Engel SM , Klein-Gitelman MS , Beaumont JL A good responsiveness for PGA was shown in eight studies. PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. Identification of new candidate drugs for primary Sjgrens syndrome using a drug repurposing transcriptomic approach, When it looks like Behets syndrome but is something else: Differential diagnosis of Behcets syndrome: a two-centre retrospective analysis, Huge water-balloons in the belly: multiple pancreatic pseudocysts in systemic lupus erythematosus, A randomized, double-blind, placebo-controlled, parallel group study on the effects of a cathepsin S inhibitor in primary Sjgrens syndrome, How to plug the leaky pipeline in clinical rheumatology across Europelessons to be learned from experiences in business, About the British Society for Rheumatology, British Society for Rheumatology Journals, https://doi.org/10.1093/rheumatology/keaa383, https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 British Society for Rheumatology. , Floris A Objective Existing methods for grading lupus flares or improvement require definition-based thresholds as increments of change. 2014 Sep-Oct;10(5):309-20. doi: 10.1016/j.reuma.2014.01.012. , Criscione-Schreiber LG et al. It is unclear when or with what justification the physician global assessment of disease status (PhGA) was first used to assess patients with systemic . Forbess LJ Supporting the face validity property, PGA was defined the gold standard in 11 studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88] and in 32 it was used as the reference to which other activity scores were compared, such as the SLEDAI [4, 10, 13, 25, 27, 28, 31, 33, 35, 36, 41, 46, 47, 50, 51, 53, 62, 65, 68, 72, 73, 76, 81, 9699], BILAG [4, 27, 35, 36, 46, 65, 72, 73, 81, 98], SLAM [4, 72, 76, 99], LAI [68, 88], patient global assessment [81, 83, 84] and ECLAM [35]. In one study, the PGA was part of a modified score to assess disease activity in pregnancy (the SLE in Pregnancy Disease Activity Index) [51]. 2022 May;9(1):e000700. , Hambleton IR Introduction Physician global assessments of disease activity (medical doctor (MD) globals) are important outcomes. Patient-Reported Outcomes in Systemic Lupus Erythematosus. The interRR was assessed in seven studies [4, 10, 11, 36, 65, 68, 94], showing values ranging from 0.67 [68] to 0.96 [94]. et al. , Nguyen SC , Liberati A Systemic lupus erythematosus (SLE), is the most common type of lupus. At least 1 issue from each virtual tour. Reviews and case series with fewer than five patients were excluded. Epub 2014 Apr 11. Different definitions of PGA retrieved through the literature search are reported in Table1. Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus. , Patrick DL Brunner HI , Hochberg M. Wallace DJ Careers. The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. An official website of the United States government. Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease (ARD) characterized by flares and remissions. Methods This SLR was conducted by two independent reviewers in accordance with the PRISMA statement. Impact of anti-SARS-CoV-2 antibodies of different isotypes (IgA, IgG, IgM) on attainment of PGA . , Ko T COSMIN Terminology from a European Rheumatology Perspective: a Glossary for the EULAR PRO Tool Box Initiative. SLE or at an SLE site, but only if the injury requires treatment by a licensed medical doctor. Bethesda, MD 20894, Web Policies , Emamikia S This potentially disfiguring disease can have significant impact on patient's quality of life (QoL) and is often refractory to many first- and second-line therapies. Vil LM In conclusion, the PGA was demonstrated to be a valid, responsive and feasible instrument, but its reliability was strongly impacted by the scale adopted, suggesting the need for standardization in its scoring. The Physician Global Assessment (PGA) of treatment response measures the overall response to treatment as assessed by the physician. The site is secure. , Devilliers H [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. Objective: The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. [35], the PGA correlated, although moderately, with the need for treatment change (r=0.46, P<0.01). Criterion validity is defined as the degree to which the scores of an instrument adequately reflect the truth in the form of a gold standard [107]. Piga M To increase its reliability, the PGA should be scored by a physician with significant expertise in SLE, with prior knowledge of laboratory results [112], considering the overall disease activity at the time of the visit and comparing it to the last visit in order to assess flares [9]. For your privacy and protection, when applying to a job online, never give your social security number to a prospective employer, provide credit card or bank account information, or perform any sort of monetary transaction. Touma Z The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. These results enabled its use as a gold standard for assessing flare and defining flare severity in several studies [21, 67, 88]. The following search strategy was used through MEDLINE via PubMed: (((lupus erythematosus, systemic[MeSH Terms] OR (lupus[TIAB] AND erythematosus[TIAB] AND systemic[TIAB]) OR systemic lupus erythematosus[TIAB] OR (systemic[TIAB] AND lupus[TIAB] AND erythematosus[TIAB]))) OR SLE[TIAB]) AND (physician global assessment[TIAB] OR PGA[TIAB]). Physician's Global Assessment Scale (PGA) or Investigator's Global Assessment Scale (IGA) measures disease status in a broad range of diseases. Thanou A, Chakravarty E, James JA, Merrill JT. , Pego-Reigosa J-M , Urowitz MB et al. , Seaman AL However, the PGA allows for the measurement of disease activity in a global way (content validity). Measurement properties of the PGA were analysed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) terminology [19]. Content validity was reported in 89 studies. , ODell JR An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were . SLE3. . The Author(s) 2020. , Kharboutli M An international panel of 79 SLE experts participated in a three-round Delphi consensus . Moreover, there is uncertainty as to whether the best timing of assessment is prior to or after reviewing laboratory exams [26]. van Vollenhoven R In this systematic review we have analysed the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. , Voskuyl A The results are similar, and less than half the time is required for scoring. Lead Medical Director heading up the global collaboration with Pfizer for Enbrel trials. One study, published after our systematic literature search was completed [112], showed that scoring the PGA with knowledge of laboratory data increased its correlation with the SLEDAI-2K (r=0.79) compared with without knowledge of laboratory results (r=0.67). MeSH Even though the PGA showed optimal reliability, a very low interRR for flare using the PGA (ICC=0.18) was found in a single study [65] compared with that of the BILAG (ICC=0.54) or SFI (ICC=0.21). This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. , Chizzolini C All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients' age. et al. Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. watch for seizures after the procedure. A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). , Dyer JW This scoring modality was used for the SRI [3]. , Taghavi-Zadeh S Barr SG National Library of Medicine PGA is a valid, responsive and feasible instrument, while its reliability was impacted by the scale adopted, suggesting the major need for a standardization of its scoring. ~SLE~. et al. Compared with nonresponders, BICLA responders had greater improvements in global and organ-specific disease activity (Physician's Global Assessment, SLE Disease Activity Index 2000, Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity, and joint counts; all nominal P < 0.001). et al. , Gomez A , Cappellazzo G Quimby KR , Alarcn GS All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients age. antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and systemic lupus erythematosus (SLE). A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.670.98). , Sjwall C. Strand V PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. AU - Louthrenoo, Worawit. Because of the complexity of SLE, the assessment of disease activity is particularly challenging [3]. Construct validity was demonstrated by a good correlation (r0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). Learn more. , Navarra SV The SRI is a validated SLE disease activity instrument used to detect clinically meaningful improvement of disease in SLE clinical trials. The visual analog scale (VAS)-based assessments, SELENA SLE Disease Activity Index (SLEDAI) Physician's Global Assessment (SSPGA) and Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL), can be used to assess common trial end points for systemic lupus erythematosus (SLE), according to study results published in Lupus Science & Medicine. [8] suggested the need for a disease activity instrument that would be valid, reliable and sensitive to change. , Petri MA , Shinada S , Fortin PR , Mokkink LB Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). In 89 studies [2, 3, 913, 21102] the PGA was used to measure disease activity as a whole, therefore satisfying the content validity criteria. et al. This button displays the currently selected search type. The official NJDOE Incident Reporting Form, as well as a guide to completing http://oml.eular.org/glossary (31 January. [80] considered worsening as any increase in the PGA from baseline; in the epratuzumab trial [87], a significant improvement was a 20% decrease in the PGA score evaluated after 12months of treatment. X 20 Physician Global Assessment 10.1136/lupus-2019-lsm.176 . Epub 2014 Jul 10. A difference between the interRR of the PGA assessed by an untrained physician (ICC=0.50.63) or a trained investigator (ICC=0.790.81) was found [36]. Before The PISCOS results will allow for increased homogeneity and reliability of PGA ratings in routine clinical practice, definitions of remission and low disease activity, and future SLE trials. , Longenecker JC 2) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99], with the SLAM in 4 studies (r=0.470.65) [35, 76, 84, 99], with LAI in 2 studies (r=0.640.75) [68, 84], with BILAG in 2 studies (r=0.610.62) [35, 84] and with ECLAM in 2 studies (r=0.580.65) [35, 84]. Results of a large, multicentric, nationwide study, American College of Rheumatology provisional criteria for global flares in childhood-onset systemic lupus erythematosus, A cross-sectional study of hydroxychloroquine concentrations and effects in people with systemic lupus erythematosus, Inactive disease and remission in childhood-onset systemic lupus erythematosus, Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus, Systemic lupus erythematosus in a multiethnic US cohort, XXXVII: association of lymphopenia with clinical manifestations, serologic abnormalities, disease activity, and damage accrual, Systemic lupus erythematosus in a multiethnic cohort (LUMINA): XXIX. Petri M et al. Nehring J , Garabajiu M All rights reserved. , Farewell V , Terwee CB This week's edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 23-March 2. , Urowitz MB. Once two investigators (E.C., M.P.) Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. Different scores and lengths of visual evaluation were employed: the first was the 010 VAS suggested by Liang et al. This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. , Borghoff K , Gladman DD. Results. It was published in 1977 and was initially designed for the measurement of self-assessed pain in rheumatoid arthritis although it has since been used to evaluate RA more globally. , Ding HH , Lau CS The literature search identified 91 studies. Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease that can occur with or without systemic lupus erythematosus (SLE). , Block JA et al. We have systematically reviewed all studies about validation of the PGA in SLE. , Tugwell P Disclaimer. Disagreements between investigators were solved by consensus. et al. , Devilliers H The PGA was integrated in composite indices, including the definition of the LLDAS [12, 13, 29, 34, 37, 39, 40] and remission [29, 37] (Table1). Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. Uribe AG, Vil LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcn GS. et al. The PGA intraRR was assessed in three studies [10, 68, 94] and ranged from 0.55 [68] to 0.88 [10]. Three studies evaluated the association between PGA scores and treatment changes: PGA correlated negatively with adherence to treatment assessed through an item scale (r=0.31, P=0.11) [34]; clinically defined mild and moderate flares had a higher disease activity by the PGA (P<0.001) than those defined as mild/moderate flare only by medication changes [55]; PGA scores were associated positively with response to belimumab treatment (P=0.039) [43]. The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). et al. Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. To discriminate between the severity of flares, the PGA was incorporated in a composite index: the SFI [10] (Table1). It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. Higher disease activity is an important predictor of both organ damage and mortality [2] and the attainment of low disease activity is associated with a reduction in early damage [5, 6]. (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). A new tool -- the Lupus Activity Scoring Tool (LAST) - has been proposed to join the ranks of current disease activity indices. , Urowitz MB. RMD Open 2018;4:e000578. , OMalley T , Lerman RH et al. Aranow C , Buyon J All rights reserved. Content validity. No study has evaluated the correlation of PGA with damage measures. Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. , Jnsen A , Wetter J , Ogale S BATCH RUBY INTENSIVE REVIEWRTRMF 3. et al. J Clin Med. The intrarater reliability (intraRR) is the ability to provide consistent scores in a stable population by the same assessor over time. et al. , Maxwell LJ The interobserver agreement between physician (PGA) and patient (PtGA) global assessment for acne and psoriasis was good, reflected by the weighted Cohen (acne, = 0.68; psoriasis, = 0.70) (eTable in the Supplement). , Magder L , Genovese M PGA is often assessed by a single question with a 0-10 or 0 .