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"d @7. No data for administration methods chosen. Caldolor (Ibuprofen): This medication, also an NSAID, is basically IV Advil. Combinations of two, three or more of these drugs occasionally need to be co-administered via syringe driver. Y-Site Compatibility Wall Charts Updated for 2020 King Guide Y-Site Compatibility Wall Charts include 123 IV drugs in 4 infusion fluids on a 27" x 27" laminated poster. Drugs administered to patients receiving PN should be given through a separate IV site or catheter lumen. You can click on the compatibility icons in the list view to see the same study list and details. Extensive TPN/TNA data. 1. Integrate our IV compatibility tool into any. COMPATIBILITY OF DRUGS COMBINED IN A SYRINGE. dry mouth , chest pain or pressure, pain spreading to the jaw or shoulder , nausea, and. Our solutions for regulated financial departments and institutions help customers meet their obligations to external regulators. Do NOT use solutions where there is a visible change in colouration. Pharm World Sci; 22(3): 88-91, 8 Tissot E, Cornette C, Demoly P, Jacquet M, Barale F, Capellier G. (1999) Medication errors at the administration stage in an intensive care unit. Search our global job market for interesting job profiles. Truven Health Analytics, the makers of Micromedex, have released multiple standalone apps, and one of them happens to be an IV compatibility checker. Mixing magnesium sulfate 50% and calcium chloride 10% results in precipitation of insoluble calcium sulfate. Possible drug/solution selections will be displayed as you continue to type. J Basic Clin Pharm; 5(2): 49-53, 5 Westbrook JI, Rob MI, Woods A, Parry D. (2011) Errors in the administration of intravenous medications in hospital and the role of correct procedures and nurse experience. 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It is used to reduce mild to moderate pain, inflammation and has some ability to reduce fever. New items will appear in the "Selected Items" field. Handbook on injectable drugs. BHz8DOGvcPoHH~` iNJ2)uIarvCmWp(l 6%{k`7;I;B+ H& 4T "!U=/p aQ]N{iT2,&dOK.~;.u;Oyem~/Q_s(d;;HMYE -"bpVghUmM01@#nS|x5213$qHfd6hAH%icIsI5sR%> `$`S_?) This can include the rinsing of the infusion system with a neutral IV solution prior to the application of another drug. Available as a single . Not all products are registered and approved for sale in all countries or regions. Some cannot be safely diluted in infusion bags. 2 RCN (2010) Royal College of Nursing. View the full Trissels monograph for more information on the physical and chemical characteristics of the drug. 62 0 obj <>stream While published compatibility data exist for insulins and some of the blood products, most recently marketed biological drugs such as infliximab, interferons and recombinant coagulation factors have no such data available and mixing with other drugs is not recommended. Our COVID-19 information hub has important information for everyone, including resources about vaccines and treatments. Many of these may be due to differences in concentrations of either drug or in the solution diluent. Visit our global site, or select a location. You can also view different drugs and solutions that are compatible by clicking the drop-down arrows. Incompatibility between infusion-bolus was found to be 26.6%. The selected drug(s) and solution(s) will populate the Selected Items in the left pane. Fig. Some incompatibilities are eminently predictable from simple chemical knowledge, but most compatibilities and incompatibilities are not so easily predicted. Incompatibilities of drugs in standard IV therapy can occur between: The unintended presence of precipitation and toxic products can cause various negative consequences for the patient. INTRAVENOUS COMPATIBILITY CHART Acyclovir ** Acyclovir ? diluent, IV container, IV lines) and the infusion regimen. Call your doctor for medical advice about serious . Practical information, tools and resources for health professionals and staff to help improve the quality of health care and safety for patients. Please allow at least 3 seconds for click feedback on this limited version. This site complies with the HONcode standard for trust- worthy health information: verify here. Making safe and wise decisions for biological disease-modifying antirheumatic drugs (bDMARDs) and other specialised medicines. The King Guide has been updated quarterly since 1971 and is an excellent addition to any drug information library with complete monographs for over 600 injectable drugs. In editis INTRAVENOUS COMPATIBILITY CHART - Drug Information For The . The new ASHP Injectable Drug Information now delivers the same quality of information you expect from ASHP, but expanded to deliver more information you . The absence of any visible change to a solution upon mixing does not automatically exclude degradation of either or both components. Please start a free trial to access the full functionality. To search on compatibility information, begin by typing the desired drug or solution name into the appropriate search box. Two syringes taped together sounds like a recipe for disaster' date=' either for the patient or for the nurse - particularly with regard to increased risk for needle sticks. Drug Name Dose &/or Range Administration Compatibility Precautions Ketamine 1-2mg/kg Low dose for analgesia . Midazolam (Versed) YES Midazolam (Versed) YES Midazolam (Versed) ** View Text Version Copyright Report Standards for Infusion Therapy. IV Drug Compatibility 12+ ITDCS Ltd Designed for iPad 1.3 16 Ratings $2.99 Screenshots iPad iPhone This application provides the healthcare profession with a method of quickly checking the compatibility of any two of the following intravenous drugs at the Y-site: Acetylcysteine Adrenaline Alfentanil Aminophylline Amiodarone Aprotinin endstream endobj 14 0 obj <>stream Sodium bicarbonate and mannitol solutions should not be used as diluent for intravenous drug administration. Key points The table provides a guide to medication compatibility via Y-site within the NICU. To view compatibility results for a list of drugs, enter multiple IV drugs and/or solutions then click "Analyze". For a drug molecule which acts as a proton acceptor (a Lowry-Bronsted base), ionisation is achieved by formulation in a low pH solution usually as a hydrochloride or hydrogen sulfate salt (for example, amiodarone hydrochloride or adrenaline acid tartrate). 14th ed. http://www.ncbi.nlm.nih.gov/pubmed/17937330, drugs and inappropriate IV solutions as diluent, two drugs (drug-drug incompatibility) when they are, drugs and adjuvants (preservative, buffer, stabilizer, solvent). 9787 0 obj <> endobj .1-.15mg/kg repeat q15 mins : Max .3mg/kg or 50mg . Keep track of medicines and access important health info any time and anywhere, especially in emergencies. The IV drug compatibility chart is based on information from the, ThisIVDrugCompatibilityChartisprovidedasaquickr, itisadvisedthatyoucheckwithapharmacistforr. This application provides the healthcare profession with a method of quickly checking the compatibility of any two of the following intravenous drugs at the Y-site: Acetylcysteine. You can return to the Chart display by toggling back to Chart View. This website uses cookies. Full information can be obtained from your pharmacy department Key References Adrenaline 18 1 Compatible (Reference 1) 1 "Handbook of Injectable Drugs" Lawrence Trissel available on www.medicinescomplete.com Select a second drug the same way (limited to 2 drugs) 3. Do Not Copy, Distribute or otherwise Disseminate without express permission. 2 below shows the results of a calculation for selected examples of complications. Reference texts can provide information, but data are often unavailable for new drugs. Reasonable care is taken to provide accurate information at the time of creation. Search for the two antibiotics, aztreonam and clindamycin, one at a time. Mixing solutions of parenteral drugs is generally not recommended because of the potential for incompatibility and consequent loss of activity of one or both drugs. %PDF-1.5 % Thyroid disease: challenges in primary care, To mix or not to mix compatibilities of parenteral drug solutions, difficulties with venous access limiting the number of intravenous lines available for continuous administration of multiple drugs, multiple drugs requiring parenteral administration within a short time frame such as in a home visit by a general practitioner. Chemical stability studies, however . In order to facilitate the attribution of each complication to the cost calculation, severity levels were introduced. Lexicomp Trissels IV Compatibility Databases. To clear the items from the tool, click the Clear button. Qual Saf Health Care; 14(3): 190-195, 12 Riemann T, Schrder F. (2005) More effective prevention of incompatibility reactions through the use of four lumen central venous catheters in critically ill patients. Each sample was prepared in duplicate and performed at room temperature. The Australian recommendations for the use of antibiotics in the prevention of endocarditis have been revised by Therapeutic Guidelines. Specialized in clinical effectiveness, learning, research and safety. 1 Fahimi F, Sefidani Forough A, Taghikhani S, Saliminejad L. (2015) The rate of Physicochemical Incompatibilities, Administration Errors. Morphine: A narcotic pain reliever, morphine is used to reduce moderate to severe pain. It is a list of 33 antibiotics and their given stability in several different solutions. IV injection due to hypotension, bradycardia, and arrhythmias. No more over sizedcharts. Please contact your country representative for product availability and information. New compatibility information was added to the existing drug monograph for AMPHOTERICIN B, BUMETANIDE, FOSFOMYCIN DISODIUM, PLAZOMICIN, SCOPOLAMINE HYDROBROMIDE, and IMIPENEM, CILASTATIN AND RELEBACTAM with 28 other drugs. Biological substances including blood products and insulin are prone to denaturation when exposed to variations in pH and osmolality. Each monograph contains stability data, administration guidelines, and methods of preparation. Y = compatible for at least 30 minutes P = provisionally compatible; give within 15 minutes P(5) = provisionally compatible; give within 5 minutes . {W } 6AEMJ0MzJ@Rb:`1"8]"nhHJ83]DbFXHZtLQ65+:v5 IzB&fFWN`SgJpRz4ObQL W`&T\R VR. King Guide to Parenteral Admixtures Online Edition. Find out more about the antiviral medicines helping to treat COVID-19. a Abciximab (reopro) Acetaminophen Acetazolamide (Diamox ) Acetylcysteine Acyclovir - Zovirax ADAKVEO (crizanlizumab-tmca) ADUHELM (aducanumab-avwa) AKYNZEO (netupitant-palonosetron) Albumin Alteplase Ambisome (amphotericin B) Amikacin Aminocaproic Acid - Amicar Aminophylline Amiodarone Ampho B Lipid Complex (abelcet) Amphotec Amphotericin B High-Risk IV Medications Dosing Limits Guidelines of Care The purpose of this tool kit is to provide evidenced-based recommendations and best practices on setting and managing high-risk IV medications limit settings for adult patients in intensive and acute care units. rtPLf/qZCF{AR1$gx4sB= A change in visible or electronically (even if not visible) particulates, haziness, or turbidity, frank precipitation, color or gas evolution occurred. hbbd```b``:"g[A$$)i"eAti"C$40D?Hh _#)Pd?= 1S5 When both drugs are present in the "Drug List" on the left, click the "Run Report" button. Copyright 1993-2021 Read our full disclaimer. A separate license is required for each facility location and we offer discounts for multiple licenses. Disclaimer: This IV Drug Compatibility Chart is provided as a quick reference, however since information is . Over 600 IV drugs with at-a-glance view of compatibility in 12 fluids. To view compatibility results for a list of drugs, enter multiple IV drugs and/or solutions then click "Analyze". X^P7&+5 Find information on medicines by active ingredient or brand name. and on the type of drug administered. IV medication must be cleared by flushing at the same rate of administration to avoid the . Fig. sweating. While some general principles can be applied to the mixing of injection solutions, they are fraught with exception and applicability varies with circumstance. In-line filters are able to retain solid particles of at least 0.2 m. The most prominent example of a pH-related reduction in solubility is dilution of phenytoin sodium injection. hb```,Q ea8p3$H``h Drug Name Dose &/or Ranges Administration Compatibility Precautions Adenosine (adenocard) First dose 6mg, repeat within 1-2 minutes at . If you really do court, make a point of conversation about your welfare and well-being. Intensive Care Med; 38(6):1 008-16, 14 Gianino MM, Vallino A, Minniti D, Abbona F, Mineccia C, Silvaplana P and Zotti CM. Glucose 5% infusion solution, which has a pH of 4.3-4.5, will precipitate phenytoin almost immediately. adsorption). This was the third project that I was assigned at Oconee Medical center. particulate emboli from crystallization and separation, tissue irritation due to major pH changes. Author E L Gordon PMID: 3637148 No abstract available MeSH terms Drug Combinations* Drug Incompatibility* Rare side effects of Nitroglycerin IV include: none. Medication compatibilities are concentration, temperature and light dependent. A number of references, in addition to the manufacturer's product information, are available. The booklet versions of Therapeutic Guidelines: Antibiotic and Therapeutic Guidelines: Oral and Dental will be updated when new editions are published. J Res Pharm Pract; (1): 37-40. When a drug or solution name is in the Selected Items section, a link to the Trissels monograph for that drug/solution will be displayed. This is because of higher mutual drug concentrations and potentially greater pH changes in the more concentrated solution. NPS MedicineWise disclaims all liability (including for negligence) for any loss, damage or injury resulting from reliance on or use of this information. To prevent dangerous incompatibilities and ensure safe patient treatment, it is important to combine various actions in different processes. Don't let the courthouse door close on you. Empowering physicians with fast, accurate clinical answers, Beyond the call: How to differentiate your telehealth experience post-visit, Implementing 2023 updates to your Antimicrobial Stewardship Program. Indications of use may also vary by country and region. Adrenaline. i\ M, u=UZ"UiCjJ; &0tOQsy pj/N&]W&/iqh&hIiM7DwZYm- j{jA[;N`9T`xk`U MM>)y@ofS5Nk5zv|\\)y9 ?;~20CLw}tb,G"5nDWyQ(EKQ}L%IzoJO*@z. A visual check for precipitation, turbidity or colour change should be carried out before administering the mixture, but does not guarantee compatibility. Physical compatibility studies are the most common of all because they are easy to conduct. About this app. Table 2: Compatible IV . hbbd``b` $6 HpHpX ^-HiL]%@JXZ0z@y#L@^ ~ Download the free Micromedex IV Compatibility app from iTunes or Google Play. 2. Select a drug or solution by clicking the Enter key on your keyboard or by using the Add button. This reference contains standard dilutions including IV admixture drug concentration, infusion volumes, and infusion rates. medication compatibility chart I.v. In some cases, the manufacturer recommends administration of the undiluted drug. Refer to drug manufacturer's labeling and use instructions for recommendations, USP <797>, and applicable institution policy for shelf life and sterility information of reconstituted product and admixture device compatibility. The test drug in a solution was stable in one container type but not another or with some drug delivery devices but not others. Special Sections on Stability and Storage When two drug solutions are mixed together the absence of a visible reaction does not exclude degradation of either drug. On$a }; In chart view, you can filter the table to display just the Y site results. Conversely, for a drug molecule which can lose a proton or hydrogen ion (a Lowry-Bronsted acid - usually a weak organic acid), ionisation is achieved by formulation in a high pH solution, usually as a sodium or potassium salt (for example, benzylpenicillin sodium). There B Bianca Paola 115 followers %%EOF Do not . Trissel LA. 574 0 obj <> endobj 610 0 obj <>/Encrypt 575 0 R/Filter/FlateDecode/ID[<7C5275BC3D5C496FB588ACDF9629EDDA>]/Index[574 66]/Info 573 0 R/Length 145/Prev 963922/Root 576 0 R/Size 640/Type/XRef/W[1 2 1]>>stream Copyright 2021 GlobalRPH - Web Development by, IV Dilutions Medication Reference and Infusion Guidelines, Renal dosing for healthcare professionals, HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. The cost can be calculated using the average daily costof the expected clinical treatment. Read in online version de INTRAVENOUS COMPATIBILITY CHART - Drug Information For The .. Download page 1-6 in FlipHTML5. The extent of the damage mainly depends on the patients condition (age, weight, nature, severity of the disease etc.) Consistently checking alternative modes of administration and/or using multi-lumen catheters. The most obvious case of pH reduction in solubility is the dilution of sodium phenytoin injection. Anaesthesist; 52(5): 409-12, 10 Taxis K, Barber N. (2004) Incidence and severity of intravenous drug errors in a German hospital. Trusted clinical technology and evidence-based solutions that drive effective decision-making and outcomes across healthcare. Discover your career opportunities at B. Braun. (2005) Medication errors in intravenous drug preparation and administration: a multicentre audit in the UK, Germany and France. Drug Compatibility : FETROJA solution for administration is compatible with: 0.9% sodium chloride injection, USP Amiodarone (Cordarone) IV Infusion IV Infusion IV Infusion: A-fib rate control only . 20 years of helping Australians make better decisions about medicines, medical tests and other health technologies. Of the 196 co-infusions, 110 had additional restrictions on time in solution. Fig. However, a small number of injection solutions are formulated in non-aqueous solvents to allow dissolution of a poorly water soluble substance in a small volume. In other cases, care needs to be taken to ensure that if the injection solution is diluted, the dilution is adequate to ensure continuing solubility over the duration of the infusion. Click the relevant option after each search. One or more drug components in the test samples exhibited a loss of intact drug greater than 10% within 24 hours under the conditions being tested. There are a number of drugs that are commonly delivered via syringe driver to patients having palliative care in the community (see box). Methods: historic cohort (retrospective) with 110 adults in critical units. COMPATIBILITY Compatibility is dependent on the concentration of each medication in the total final volume being infused, rather than the actual dose. To view all solution and drug compatibility results for a single drug, enter the IV Drug and Click "View Compatibility". Incompatibility is present when visible or electronically-determined precipitates, particulates, haziness, turbidity, color, or gas evolution are detected. 2021, 2022 Doody's Core Titles List Selection I 5-Star Rating from Doody's Review Service For more than 40 years ASHP has published the most trusted resource for injectable drug information. PN solutions are diverse in their composition and compatibilities with drugs can never be guaranteed. Table. The single user license allows access from any computer or device from any location and limits access to one person at a time while the site license allows access from an unlimited number of computers or devices. David McAuley, Pharm.D. All drug components in the test samples were found to be chemically stable (less than 10% loss of intact drug) for at least 24 hours under the conditions being tested. In this update we added a new monograph for TOCILIZUMAB. All content is available on the global site. Iran J Pharm Res; 14(suppl); 87-93. The compatibility results are presented in a chart or list view, with the default chart view displaying all methods within the fields for the selected drugs and solutions. The problem is frequently observed when diazepam injection is diluted. To add drugs to be compared, the user only has to . (2000) Evaluation of physicochemical incompatibilities during parenteral drug administration in a paediatric intensive care unit. Further publications showed that, depending on the ward type, up to 80% of IV drug doses were prepared with the wrong diluents.11. Definitions for the following types of compatibility testing are as follows: The compatibility information presented is based on one of four (4) ratings: In the chart display, find detailed information about a specific pair of drugs and administration route by clicking on the compatibility type link within the table. In one study, incompatibility was investigated in a pediatric intensive care ward showing that 3.4% of drug combinations were incompatible and thus potentially dangerous.7A life threatening nature was found for 26% of incompatibilities in an intensive care unit (ICU).8, Another survey collected 78 different medication regimes and found 15% with incompatibility reactions.9Taxis and Barber10reported that in the ICU clinical incompatibilities can contribute to 25% of medication errors. Y-Site, Syringe, and other sets/container specific information. Intensive Care Med; 25(4): 353-9, 9 Vogel Kahmann I, Brki R, et al. A red I means the drugs are incompatible, and an orange U symbol means there are conflicting reports. All Rights Reserved. This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. In the chart display, each compatibility pair has an indicator for the type of result found. Mixing solutions containing calcium or magnesium ions has a substantial risk of forming an insoluble calcium or magnesium salt. Five years after the implementation of a simple "colour code system". arrow_forward. Enter one drug and click View compatibility. The default compatibility result will display the solution compatibilities for the IV Drug searched. Any other research result that does not fit the conventional guidelines of compatibility or incompatibility. Compatibility analyses can also be viewed in a list display, where results are shown in pairs. 3. Prescription and OTC drugs (over 100,000 drug products), 900+ nutraceuticals, including herbal medicines, Presented in prescriptive, immediately actionable bullet points for busy clinicians and students. What makes a difference? All rights reserved. hXmo8+UEw'EUBJRmwNBRb8x0_N%p F9)c'R&(a&LH*$("A7(P&|I#\(NU?ANI"4R`2DVT@0AX|N4nE`] 4IV,\;{^Q8q9bcFO>C@Do\#+Uhju}4wQTLG/| {0pR(7%?$sM7kB(h9hY* ^?r37HE2hHGp0JE~fqpyzlFE'&abRoXIPoTD L ExUoib:"nt/x]q>=YZ+Bc#,%3}~(qYKjs@x' ? Click on "Trissel's IV Compatibility" to open the module. The Fig. 36 0 obj <>/Filter/FlateDecode/ID[<0362003AF2051D05883835398FF34BC1><94CA9B80B28C4046B8C68869BA50C87B>]/Index[10 53]/Info 9 0 R/Length 109/Prev 52998/Root 11 0 R/Size 63/Type/XRef/W[1 2 1]>>stream Individual labelling for each drug preparation (including drug, concentration, patient name). Serving legal professionals in law firms, General Counsel offices and corporate legal departments with data-driven decision-making tools. Step 1. Incompatibility between infusion-bolus was . 194 0 obj <>stream Fortunately, King Guide, the oldest continuously published reference on parenteral drug stability and compatibility, is designed to provide practitioners with the timely information they need in this era of drug shortages. Data sources: Published articles, nursing and pharmacology . Complete pharmacokinetic information includes the mechanism and absorption of the drug, as well as its action, duration, and excretion. drugs and materials of IV containers (e.g. @z0012c`,' PEPIDs IV Compatibility Checker is available through any of our clinical decision support suites, allowing healthcare professionals to quickly check the compatibility of specific IV sites, drugs and solutions with their mobile devices oronline. HK9D:E?FDg#{p*+ >^qnr YVNOBe/[\xwGj?LndXrn^-5 ,}c}ym)Ar&/(Z$$m{{}NYrT*#@-fI($y'[iRugP^2+ wy D63Hr=bW.X=3$o]$fr5\F0#7B/Le!xtPqBllZ'dgc~vA1+ %PDF-1.6 % 164 0 obj <>/Filter/FlateDecode/ID[<2786D62A495E4BAFB8F09C87CC37D585>]/Index[140 55]/Info 139 0 R/Length 108/Prev 379717/Root 141 0 R/Size 195/Type/XRef/W[1 2 1]>>stream Murney P. To mix or not to mix compatibilities of parenteral drug solutions. We would be pleased to provide you with more information. The salts of monovalent cations, such as sodium and potassium, are generally more soluble than those of divalent cations, such as calcium and magnesium. In dialog with B. Braun. Cs = Compatible Only if Drugs mixed in NS CD = Compatible Only if Drugs mixed in Dextrose C* =Conc./Time dependent, CALL PHARMACY dextrose IV soln. The compatibility results are presented in a chart or list view, with the default chart view displaying all methods within the fields for the selected drugs and solutions. Improving clinical practice and health outcomes for Australia. In addition, 196 of the 212 (93%) had restrictions on infusion fluid, contact time or concentration, and for 116 of these 196 (59%) there were limitations on the duration of stability. 1. [/quote'] Wolters Kluwer is a global provider of professional information, software solutions, and services for clinicians, nurses, accountants, lawyers, and tax, finance, audit, risk, compliance, and regulatory sectors. PflegenIntensiv; 2(1): 57, 13 Jack T, Boehne M, Brent BE, Hoy L, Kditz H, Wessel A, Sasse M. (2012)In-line filtration reduces severe complications and length of stay on pediatric intensive care unit: a prospective, randomized, controlled trial. Use reference materials to find incompatibility, compatibility, and storage information. In this guide, infusion durations are for 24 hours. Ensure drug-solution and drug-drug-solution compatibility across various IV ports, syringes and additives prior to mixing. A method to determine hospital costs associated with nosocomial infections (transl), Ann Ig 2007; 19(4): 381-392http://www.ncbi.nlm.nih.gov/pubmed/17937330. Explain visual inspection of a parenteral solution. Drug pairs with conflicting compatibility results may often have different concentrations used or other differences to account for the variability. saline IV Soln: dex/Na/K IV soln < 1 unit/mL heparin PN (NO heparin) PN (with heparin) intralipids (fats) alprostadil (PGE1) amiodarone: calcium CHLORIDE calcium GLUCONATE: PVC) or medical devices, which can concern the nature of the material used and/or reactions at the inner surface (e.g. -nF1tih$HPCQ7rGceww~@3HWw!n,GE,"? .+!+I9T4 _ OR{|)ixe3 All rights reserved. Relevant, timely and evidence-based information for Australian health professionals and consumers. An internet connection is not required, allowing you to make decisions with confidence at anytime, from anywhere. medication compatibility chart Crit Care Nurse. Use the reset filter button to go back to the default view. e^QHv` % Available for Critical Care Admixtures or Chemotherapy. Hawthorn, Vic. A recent warning has been issued about mixing calcium-containing solutions, including Hartmann's solution, with ceftriaxone causing the formation of the insoluble ceftriaxone calcium salt.1. ^P}M%@586:vaX-KF\6c:Zj;C8r8&}+MDU_M iVg 6qiv |fZ~d,NDF+ mTI\uPxuPh)":H"3&"Xz M9|AqouXOKX3ZuJ&!q\&`1 ,5 &l5@`,[%h6agz6SM0@ &cuu Dilution of injectable phenytoin by adding it to an infusion bag lowers its pH and therefore reduces its solubility resulting in precipitation of the drug. This trial version of the IV-Compatibility Checker is not currently being maintained and may not feature updated information. IV drug compatibility in critical care Abstract: Objectives: To analyze potential (in)compatibilities of intravenous drugs based on the scheduling prepared by the nursing team. To determine the physical intravenous Y-site compatibility of 19 commonly used medications at pediatric concentrations with 3 different types o . Klin Padiatr; 219(1): 37-43, 7 Gikic M, Di Paolo ER, Pannatier A, Cotting J. The mixing of drug salts of calcium, and to a lesser extent magnesium, with phosphates, carbonates, bicarbonates, tartrates or sulfates should also be avoided. Get in touch with us.